Unraveling the interplay between norovirus infection, gut microbiota, and novel antiviral approaches: a comprehensive review.

ABSTRACT: Norovirus infection is a leading cause of acute gastroenteritis worldwide and can also cause harmful chronic infections in individuals with weakened immune systems. The role of the gut microbiota in the interactions between the host and noroviruses has been extensively studied. While most past studies were conducted in vitro or focused on murine noroviruses, recent research has expanded to human noroviruses using in vivo or ex vivo human intestinal enteroids culture studies. The gut microbiota has been observed to have both promoting and inhibiting effects on human noroviruses. Understanding the interaction between noroviruses and the gut microbiota or probiotics is crucial for studying the pathogenesis of norovirus infection and its potential implications, including p

SUBMITTER: Bai GH 

PROVIDER: S-EPMC10359435 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature