Gut microbiota metabolites mediate the interplay between childhood maltreatment and psychopathology in patients with eating disorders.

ABSTRACT: Eating disorders (EDs) are syndromes with a multifactorial etiopathogenesis, involving childhood traumatic experiences, as well as biological factors. Human microbiome has been hypothesised to play a fundamental role, impacting on emotion regulation, as well as with eating behaviours through its metabolites such as short chain fatty acids (SCFAs). The present study investigated the interactions between psychopathology of EDs, the gut microbiome and SCFAs resulting from bacterial community metabolic activities in a population of 47 patients with Anorexia Nervosa, Bulimia Nervosa, and Binge Eating Disorder and in healthy controls (HCs). Bacterial gut microbiota composition differences were found between subjects with EDs and HCs, especially in association with different pathological behaviou

SUBMITTER: Castellini G 

PROVIDER: S-EPMC10359458 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature