Integration of transcription coregulator complexes with sequence-specific DNA-binding factor interactomes.

ABSTRACT: The domain of transcription regulation has been notoriously difficult to annotate in the Gene Ontology, partly because of the intricacies of gene regulation which involve molecular interactions with DNA as well as amongst protein complexes. The molecular function 'transcription coregulator activity' is a part of the biological process 'regulation of transcription, DNA-templated' that occurs in the cellular component 'chromatin'. It can mechanistically link sequence-specific DNA-binding transcription factor (dbTF) regulatory DNA target sites to coactivator and corepressor target sites through the molecular function 'cis-regulatory region sequence-specific DNA binding'. Many questions arise about transcription coregulators (coTF). Here, we asked how many unannotated, putative coregulators ca

SUBMITTER: Velthuijs N 

PROVIDER: S-EPMC10359485 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature