Ontology highlight
ABSTRACT:
SUBMITTER: Sundararaman B
PROVIDER: S-EPMC10359599 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Sundararaman Balaji B Vershinina Alisa O AO Hershauer Samantha S Kapp Joshua D JD Dunn Shelby S Shapiro Beth B Green Richard E RE
Nucleic acids research 20230701 13
Hybridization capture approaches allow targeted high-throughput sequencing analysis at reduced costs compared to shotgun sequencing. Hybridization capture is particularly useful in analyses of genomic data from ancient, environmental, and forensic samples, where target content is low, DNA is fragmented and multiplex PCR or other targeted approaches often fail. Here, we describe a DNA bait synthesis approach for hybridization capture that we call Circular Nucleic acid Enrichment Reagent, or CNER ...[more]