Ontology highlight
ABSTRACT:
SUBMITTER: Liu D
PROVIDER: S-EPMC10359621 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Nucleic acids research 20230701 13
The interferon inducible protein 16 (IFI16) is a prominent sensor of nuclear pathogenic DNA, initiating innate immune signaling and suppressing viral transcription. However, little is known about mechanisms that initiate IFI16 antiviral functions or its regulation within the host DNA-filled nucleus. Here, we provide in vitro and in vivo evidence to establish that IFI16 undergoes liquid-liquid phase separation (LLPS) nucleated by DNA. IFI16 binding to viral DNA initiates LLPS and induction of cyt ...[more]