The broad-spectrum activity of perampanel: state of the art and future perspective of AMPA antagonism beyond epilepsy.

ABSTRACT: Glutamate is the brain's main excitatory neurotransmitter. Glutamatergic neurons primarily compose basic neuronal networks, especially in the cortex. An imbalance of excitatory and inhibitory activities may result in epilepsy or other neurological and psychiatric conditions. Among glutamate receptors, AMPA receptors are the predominant mediator of glutamate-induced excitatory neurotransmission and dictate synaptic efficiency and plasticity by their numbers and/or properties. Therefore, they appear to be a major drug target for modulating several brain functions. Perampanel (PER) is a highly selective, noncompetitive AMPA antagonist approved in several countries worldwide for treating different types of seizures in various epileptic conditions. However, recent data show that PER can potenti

SUBMITTER: Perversi F 

PROVIDER: S-EPMC10359664 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature