Biomimetic hydrogel derived from decellularized dermal matrix facilitates skin wounds healing.

ABSTRACT: Cutaneous wound healing affecting millions of people worldwide represents an unsolvable clinical issue that is frequently challenged by scar formation with dramatical pain, impaired mobility and disfigurement. Herein, we prepared a kind of light-sensitive decellularized dermal extracellular matrix-derived hydrogel with fast gelling performance, biomimetic porous microstructure and abundant bioactive functions. On account of its excellent cell biocompatibility, this ECM-derived hydrogel could induce a marked cellular infiltration and enhance the tube formation of HUVECs. In vivo experiments based upon excisional wound splinting model showed that the hydrogel prominently imparted skin wound healing, as evidenced by notably increased skin appendages and well-organized collagen expressi

SUBMITTER: Yu Y 

PROVIDER: S-EPMC10359665 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature