Underrepresented Populations in Parkinson's Genetics Research: Current Landscape and Future Directions.

ABSTRACT:

Background

Human genetics research lacks diversity; over 80% of genome-wide association studies have been conducted on individuals of European ancestry. In addition to limiting insights regarding disease mechanisms, disproportionate representation can create disparities preventing equitable implementation of personalized medicine.

Objective

This systematic review provides an overview of research involving Parkinson's disease (PD) genetics in underrepresented populations (URP) and sets a baseline to measure the future impact of current efforts in those populations.

Methods

We searched PubMed and EMBASE until October 2021 using search strings for "PD," "genetics," the main "URP," and and the countries in Latin America, Caribbean, Africa, Asia, and Oceania (excluding Aus

SUBMITTER: Schumacher-Schuh AF 

PROVIDER: S-EPMC10360137 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature