An empirical model of proton RBE based on the linear correlation between x-ray and proton radiosensitivity.

ABSTRACT:

Background

Proton relative biological effectiveness (RBE) is known to depend on physical factors of the proton beam, such as its linear energy transfer (LET), as well as on cell-line specific biological factors, such as their ability to repair DNA damage. However, in a clinical setting, proton RBE is still considered to have a fixed value of 1.1 despite the existence of several empirical models that can predict proton RBE based on how a cell's survival curve (linear-quadratic model [LQM]) parameters α and β vary with the LET of the proton beam. Part of the hesitation to incorporate variable RBE models in the clinic is due to the great noise in the biological datasets on which these models are trained, often making it unclear which model, if any, provides sufficiently accurate RBE p

SUBMITTER: Flint DB 

PROVIDER: S-EPMC10360139 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature