Copper-Mediated Dehydrogenative C(sp³)-H Borylation of Alkanes.

ABSTRACT: Borylations of inert carbon-hydrogen bonds are highly useful for transforming feedstock chemicals into versatile organoboron reagents. Catalysis of these reactions has historically relied on precious-metal complexes, which promote dehydrogenative borylations with diboron reagents under oxidant-free conditions. Recently, photoinduced radical-mediated borylations involving hydrogen atom transfer pathways have emerged as attractive alternatives because they provide complimentary regioselectivities and proceed under metal-free conditions. However, these net oxidative processes require stoichiometric oxidants and therefore cannot compete with the high atom economy of their precious-metal-catalyzed counterparts. Herein, we report that CuCl₂ catalyzes radical-mediated, dehydrogenative

SUBMITTER: Sang R 

PROVIDER: S-EPMC10360158 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature