Defining critical illness using immunological endotypes in patients with and without sepsis: a cohort study.

ABSTRACT:

Background

Sepsis is a heterogenous syndrome with limited therapeutic options. Identifying immunological endotypes through gene expression patterns in septic patients may lead to targeted interventions. We investigated whether patients admitted to a surgical intensive care unit (ICU) with sepsis and with high risk of mortality express similar endotypes to non-septic, but still critically ill patients using two multiplex transcriptomic metrics obtained both on admission to a surgical ICU and at set intervals.

Methods

We analyzed transcriptomic data from 522 patients in two single-site, prospective, observational cohorts admitted to surgical ICUs over a 5-year period ending in July 2020. Using an FDA-cleared analytical platform (nCounter FLEX^®, NanoString, Inc.), we

SUBMITTER: Balch JA 

PROVIDER: S-EPMC10360294 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature