Ontology highlight
ABSTRACT:
SUBMITTER: Ascierto PA
PROVIDER: S-EPMC10360352 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Ascierto Paolo A PA Avallone Antonio A Bifulco Carlo C Bracarda Sergio S Brody Joshua D JD Emens Leisha A LA Ferris Robert L RL Formenti Silvia C SC Hamid Omid O Johnson Douglas B DB Kirchhoff Tomas T Klebanoff Christopher A CA Lesinski Gregory B GB Monette Anne A Neyns Bart B Odunsi Kunle K Paulos Chrystal M CM Powell Daniel J DJ Rezvani Katayoun K Segal Brahm H BH Singh Nathan N Sullivan Ryan J RJ Fox Bernard A BA Puzanov Igor I
Journal of translational medicine 20230720 1
The discovery and development of novel treatments that harness the patient's immune system and prevent immune escape has dramatically improved outcomes for patients across cancer types. However, not all patients respond to immunotherapy, acquired resistance remains a challenge, and responses are poor in certain tumors which are considered to be immunologically cold. This has led to the need for new immunotherapy-based approaches, including adoptive cell transfer (ACT), therapeutic vaccines, and ...[more]