The role of m⁶A and m⁶Am RNA modifications in the pathogenesis of diabetes mellitus.

ABSTRACT: The rapidly developing research field of epitranscriptomics has recently emerged into the spotlight of researchers due to its vast regulatory effects on gene expression and thereby cellular physiology and pathophysiology. N⁶-methyladenosine (m⁶A) and N⁶,2'-O-dimethyladenosine (m⁶Am) are among the most prevalent and well-characterized modified nucleosides in eukaryotic RNA. Both of these modifications are dynamically regulated by a complex set of epitranscriptomic regulators called writers, readers, and erasers. Altered levels of m⁶A and also several regulatory proteins were already associated with diabetic tissues. This review summarizes the current knowledge and gaps about m⁶A and m⁶Am modifications and their res

SUBMITTER: Benak D 

PROVIDER: S-EPMC10360938 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature