γδ T cell-intrinsic IL-1R promotes survival during Staphylococcus aureus bacteremia.

ABSTRACT: Staphylococcus aureus is a leading cause of bacteremia, further complicated by the emergence of antibiotic-resistant strains such as methicillin-resistant S. aureus (MRSA). A better understanding of host defense mechanisms is needed for the development of host-directed therapies as an alternative approach to antibiotics. The levels of IL-1, IL-17, and TNF-α cytokines in circulation have been associated with predictive outcomes in patients with S. aureus bacteremia. However, their causative role in survival and the cell types involved in these responses during bacteremia is not entirely clear. Using a mouse model of S. aureus bacteremia, we demonstrated that IL-17A/F and TNF-α had no significant impact on survival, whereas IL-1R signaling was critical for surviva

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10361057 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature