CD11c⁺ and IRF8⁺ cell densities in rectal cancer biopsies predict outcomes of neoadjuvant chemoradiotherapy.

ABSTRACT: Approximately 20% of locally advanced rectal cancer (LARC) patients treated preoperatively with chemoradiotherapy (CRT) achieve pathologically confirmed complete regression. However, there are no clinically implemented biomarkers measurable in biopsies that are predictive of tumor regression. Here, we conducted multiplexed immunophenotyping of rectal cancer diagnostic biopsies from 16 LARC patients treated preoperatively with CRT. We identified that patients with greater tumor regression had higher tumor infiltration of pan-T cells and IRF8⁺HLA-DR⁺ cells prior to CRT. High IRF8⁺HLA-DR⁺ cell density was further associated with prolonged disease-specific survival with 83% survival at 5 y compared to 28% in patients with low infiltration. Contrastin

SUBMITTER: Tse BCY 

PROVIDER: S-EPMC10361136 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature