Shifting pattern of gut microbiota in pregnant women two decades apart - an observational study.

ABSTRACT:

Background

Past decades have witnessed a decrease in environmental biodiversity. We hypothesized a similar decrease in indigenous gut microbiota diversity, which may have contributed to the obesity epidemic.

Objective

To investigate the changes in the composition and function of the gut microbiota in pregnant women over a period of 20 years.

Study design

Altogether 124 pregnant women (41 overweight and matched 83 normal weight) pregnant in 1997, 2007 or 2017 were included in the study. The gut microbiota composition was assessed from fecal samples obtained at 32 weeks of gestation by 16S rRNA gene sequencing. Fecal short chain fatty acid (SCFA) profiles were measured by gas chromatography mass spectrometry (GC-MS).

Results

Distinct gut microbiota profiles were

SUBMITTER: Rautava S 

PROVIDER: S-EPMC10361139 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature