The relationship between the serum lipid profile and hepatocellular carcinoma in east Asian population: A mendelian randomization study.

ABSTRACT:

Background

Although several studies have found that the serum lipid profile may be correlated with hepatocellular carcinoma (HCC), the causal relationships between the serum lipid profile and HCC have not been determined due to potential confounder. Here, Mendelian randomization (MR) analysis was performed to identify the relationship between the serum lipid profile and HCC in the East Asian population.

Method

Our study made a MR analysis with the validation of two data sets. We obtained genome-wide association study (GWAS) data related to the serum lipid profile from Asian Genetic Epidemiology Network (AGEN). Then, the data from a recent large GWAS of the East Asian ancestry in Japan (BioBank Japan, BBJ) were extracted. Summary-level statistical data for HCC were obtained f

SUBMITTER: Pan GQ 

PROVIDER: S-EPMC10361312 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature