Zishen Yutai Pill improves sperm quality and reduces testicular inflammation in experimental varicocele rats.

ABSTRACT:

Objective

Zishen Yutai Pill (ZYP), containing 15 Chinese traditional medicine, is a safe and well quality-controlled TCM preparation with promising effects in many fields of reproduction. The current study was designed to investigate the therapeutic effects of ZYP on sperm quality and testis in varicocele (VC) rats.

Materials and methods

Male Wistar rats were randomly divided into four groups (n = 6), i.e., a sham group, a VC group, and VC groups treated with different dose of ZYP (1575 and 3150 mg/kg/d, respectively). The experimental VC model was established by partial ligation of left renal vein. Six weeks after model establishment, ZYP was orally administered once a day for the next 6 weeks. Parameters relating to testis and sperm quality were assessed. Hematoxylin-eosin

SUBMITTER: Peng M 

PROVIDER: S-EPMC10361325 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature