TMEM41A overexpression correlates with poor prognosis and immune alterations in patients with endometrial carcinoma.

ABSTRACT:

Background

Expression levels of transmembrane protein 41A (TMEM41A) are related to the progression of malignant tumors. However, the association between TMEM41A expression and endometrial carcinoma (EC) remains unclear. This study aims to identify the roles of TMEM41A expression in the prognosis of patients with EC and its correlation with EC progression.

Methods

The TMEM41A expression and its correlation with the survival of patients with EC were assessed. Cox regression analysis was used to identify the prognostic factors, while nomograms were used to examine the association between the prognostic factors and the survival of patients with EC. Finally, the link between TMEM41A level and immune microenvironment and RNA modifications was investigated in EC.

Results

TME

SUBMITTER: Shi K 

PROVIDER: S-EPMC10361503 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature