Central nervous system sulfatide deficiency as a causal factor for bladder disorder in Alzheimer's disease.

ABSTRACT:

Background

Despite being a brain disorder, Alzheimer's disease (AD) is often accompanied by peripheral organ dysregulations (e.g., loss of bladder control in late-stage AD), which highly rely on spinal cord coordination. However, the causal factor(s) for peripheral organ dysregulation in AD remain elusive.

Methods

The central nervous system (CNS) is enriched in lipids. We applied quantitative shotgun lipidomics to determine lipid profiles of human AD spinal cord tissues. Additionally, a CNS sulfatide (ST)-deficient mouse model was used to study the lipidome, transcriptome and peripheral organ phenotypes of ST loss.

Results

We observed marked myelin lipid reduction in the spinal cord of AD subjects versus cognitively normal individuals. Among which, levels of ST, a mye

SUBMITTER: He S 

PROVIDER: S-EPMC10361545 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature