Dataset Information

Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols.

ABSTRACT: Using a citizen science approach, we identify a country-wide exposure to aerosolized spores of a human fungal pathogen, Aspergillus fumigatus, that has acquired resistance to the agricultural fungicide tebuconazole and first-line azole clinical antifungal drugs. Genomic analysis shows no distinction between resistant genotypes found in the environment and in patients, indicating that at least 40% of azole-resistant A. fumigatus infections are acquired from environmental exposures. Hotspots and coldspots of aerosolized azole-resistant spores were not stable between seasonal sampling periods. This suggests a high degree of atmospheric mixing resulting in an estimated per capita cumulative annual exposure of 21 days (±2.6). Because of the ubiquity of this measured exposure, it is imperative that we determine sources of azole-resistant A. fumigatus to reduce treatment failure in patients with aspergillosis.

SUBMITTER: Shelton JMG

PROVIDER: S-EPMC10361594 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols.

Shelton Jennifer M G JMG Rhodes Johanna J Uzzell Christopher B CB Hemmings Samuel S Brackin Amelie P AP Sewell Thomas R TR Alghamdi Asmaa A Dyer Paul S PS Fraser Mark M Borman Andrew M AM Johnson Elizabeth M EM Piel Frédéric B FB Singer Andrew C AC Fisher Matthew C MC

Science advances 20230721 29

Using a citizen science approach, we identify a country-wide exposure to aerosolized spores of a human fungal pathogen, Aspergillus fumigatus, that has acquired resistance to the agricultural fungicide tebuconazole and first-line azole clinical antifungal drugs. Genomic analysis shows no distinction between resistant genotypes found in the environment and in patients, indicating that at least 40% of azole-resistant A. fumigatus infections are acquired from environmental exposures. ...[more]

PMID: 37478175

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Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols.

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Citizen science reveals landscape-scale exposures to multiazole-resistant <i>Aspergillus fumigatus</i> bioaerosols.

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Citizen science reveals landscape-scale exposures to multiazole-resistant Aspergillus fumigatus bioaerosols.

Publications

Citizen science reveals landscape-scale exposures to multiazole-resistant &lt;i&gt;Aspergillus fumigatus&lt;/i&gt; bioaerosols.

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OmicsDI is part of the ELIXIR infrastructure

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Citizen science reveals landscape-scale exposures to multiazole-resistant <i>Aspergillus fumigatus</i> bioaerosols.