Integrated analyses of single-cell transcriptomics identify metastasis-associated myeloid subpopulations in breast cancer lung metastasis.

ABSTRACT: Lung metastasis of breast cancer is closely associated with patient morbidity and mortality, which correlates with myeloid cells in the lung microenvironment. However, the heterogeneity and specificity of metastasis-associated myeloid cells have not been fully established in lung metastasis. Here, by integrating and analyzing single-cell transcriptomics, we found that myeloid subpopulations (Tppp3 ⁺ monocytes, Isg15 ⁺ macrophages, Ifit3 ⁺ neutrophils, and Il12b ⁺ DCs) play critical roles in the formation and development of the metastatic niche. Gene enrichment analyses indicate that several tumor-promoting pathways should be responsible for the process, including angiogenesis (Anxa1 and Anxa2 by Tppp3<

SUBMITTER: Huang Z 

PROVIDER: S-EPMC10361816 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature