Sequential CAR T cell and targeted alpha immunotherapy in disseminated multiple myeloma.

ABSTRACT: Multiple myeloma (MM) is still an incurable disorder despite improved antibody and cellular therapies against different MM antigens. Single targeted antigens have so far been ineffective against MM with most patients relapsing after initial response. Hence, sequential immunotherapies directed at different targets are expected to perform better than monotherapy alone. Here, we optimized and established in preclinical studies the therapeutic rationale of using targeted alpha therapy (TAT) directed against CD38 antigen (²²⁵Ac-DOTA-daratumumab) with CAR T cell therapy directed at CS1 antigen in a systemic MM model. The sequential therapies compared CAR T therapy followed by TAT to TAT followed by CAR T therapy. CAR T cell monotherapy increased median survival from 49 days (d) in unt

SUBMITTER: Awuah D 

PROVIDER: S-EPMC10361855 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature