Subtypes of high-grade breast ductal carcinoma in situ (DCIS): incidence and potential clinical impact.

ABSTRACT:

Objective

The purpose of this study was to investigate and classify the molecular subtypes of high-grade ductal carcinoma in situ (DCIS) and identify possible high-risk subtypes. The heterogenicity of DCIS with variable clinical and histopathological presentations has been recognized. Nevertheless, only histopathological grading and diameter are currently implemented in clinical decision-making following the diagnosis of DCIS. The molecular subtypes of DCIS and their IHC surrogate markers have not been defined in conventional treatment guidelines and recommendations. We applied the definitions of molecular subtypes according to the IHC surrogate markers defined for IBC and subclassified high-grade DCIS, accordingly.

Methods

Histopathological specimens were collected, revised

SUBMITTER: Schandiz H 

PROVIDER: S-EPMC10361903 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature