Radiomic signatures from T2W and DWI MRI are predictive of tumour hypoxia in colorectal liver metastases.

ABSTRACT:

Background

Tumour hypoxia is a negative predictive and prognostic biomarker in colorectal cancer typically assessed by invasive sampling methods, which suffer from many shortcomings. This retrospective proof-of-principle study explores the potential of MRI-derived imaging markers in predicting tumour hypoxia non-invasively in patients with colorectal liver metastases (CLM).

Methods

A single-centre cohort of 146 CLMs from 112 patients were segmented on preoperative T2-weighted (T2W) images and diffusion-weighted imaging (DWI). HIF-1 alpha immunohistochemical staining index (high/low) was used as a reference standard. Radiomic features were extracted, and machine learning approaches were implemented to predict the degree of histopathological tumour hypoxia.

Results

Radi

SUBMITTER: Bodalal Z 

PROVIDER: S-EPMC10361926 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature