Rational design of alcoholic fermentation targeting extracellular carbon.

ABSTRACT: Breeding yeast strains for industrial alcoholic fermentation requires laborious screening due to the lack of in vivo modification strategies. Here we show that quiescence-specific cell wall thickening via synthesis of a major component, 1,3-β-glucan, critically antagonizes cellular fermentation ability by sequestering the available cytoplasmic carbon sources. This study provides insights into glycolytic control and reports an effective and reliable rational fermentation design.

SUBMITTER: Watanabe D 

PROVIDER: S-EPMC10361962 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature