Diet effects on colonic health influence the efficacy of Bin1 mAb immunotherapy for ulcerative colitis.

ABSTRACT: Ulcerative colitis (UC) is an idiopathic disease of the large intestine linked to high fat-high protein diets, a dysbiotic microbiome, and a metabolome linked to diet and/or aberrant circadian rhythms associated with poor sleeping patterns. Understanding diet-affected factors that negatively influence colonic health may offer new insights into how to prevent UC and enhance the efficacy of UC immunotherapy. In this preclinical study, we found that standard or high fiber diets in mice positively influenced their colonic health, whereas a high fat-high protein diet negatively influenced colonic health, consistent with clinical findings. Animals fed a high fat/high protein diet experienced obesity and a reduced colon length, illustrating a phenotype we suggest calling peinosis [hunger-like-con

SUBMITTER: Thomas S 

PROVIDER: S-EPMC10361997 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature