Dataset Information

Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil.

ABSTRACT: The emergence and reemergence of mosquito-borne diseases in Brazil such as yellow fever, zika, chikungunya, and dengue have had serious impacts on public health. Concerns have been raised due to the rapid dissemination of the chikungunya virus across the country since its first detection in 2014 in Northeast Brazil. In this work, we carried out on-site training activities in genomic surveillance in partnership with the National Network of Public Health Laboratories that have led to the generation of 422 chikungunya virus genomes from 12 Brazilian states over the past two years (2021-2022), a period that has seen more than 312 thousand chikungunya fever cases reported in the country. These genomes increased the amount of available data and allowed a more comprehensive characterization of the dispersal dynamics of the chikungunya virus East-Central-South-African lineage in Brazil. Tree branching patterns revealed the emergence and expansion of two distinct subclades. Phylogeographic analysis indicated that the northeast region has been the leading hub of virus spread towards other regions. Increased frequency of C > T transitions among the new genomes suggested that host restriction factors from the immune system such as ADAR and AID/APOBEC deaminases might be driving the genetic diversity of the chikungunya virus in Brazil.

SUBMITTER: Xavier J

PROVIDER: S-EPMC10362057 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil.

Xavier Joilson J Alcantara Luiz Carlos Junior LCJ Fonseca Vagner V Lima Mauricio M Castro Emerson E Fritsch Hegger H Oliveira Carla C Guimarães Natalia N Adelino Talita T Evaristo Mariane M Rodrigues Evandra S ES Santos Elaine Vieira EV de La-Roque Debora D de Moraes Laise L Tosta Stephane S Neto Adelino A Rosewell Alexander A Mendonça Ana Flavia AF Leite Anderson A Vasconcelos Andreza A Silva de Mello Arabela L AL Vasconcelos Bergson B Montalbano Camila A CA Zanluca Camila C Freitas Carla C de Albuquerque Carlos F C CFC Duarte Dos Santos Claudia Nunes CN Santos Cleiton S CS Dos Santos Cliomar Alves CA Gonçalves Crhistinne C Maymone CCM Teixeira Dalane D Neto Daniel F L DFL Cabral Diego D de Oliveira Elaine C EC Noia Maciel Ethel L EL Pereira Felicidade Mota FM Iani Felipe F de Carvalho Fernanda P FP Andrade Gabriela G Bezerra Gabriela G de Castro Lichs Gislene G GG Pereira Glauco Carvalho GC Barroso Haline H Franz Helena Cristina Ferreira HCF Ferreira Hivylla H Gomes Iago I Riediger Irina N IN Rodrigues Isabela I de Siqueira Isadora C IC Silva Jacilane J Rico Jairo Mendez JM Lima Jaqueline J Abrantes Jayra J do Nascimento Jean Phellipe M JPM Wasserheit Judith N JN Pastor Julia J de Magalhães Jurandy J F JJF Luz Kleber Giovanni KG Lima Neto Lidio G LG Frutuoso Livia C V LCV da Silva Luana Barbosa LB Sena Ludmila L de Sousa Luis Arthur F LAF Pereira Luiz Augusto LA Demarchi Luiz L Câmara Magaly C B MCB Astete Marcela G MG Almiron Maria M Lima Maricelia M Umaki Zardin Marina C S MCS Presibella Mayra M MM Falcão Melissa B MB Gale Michael M Freire Naishe N Marques Nelson N de Moura Noely F O NFO Almeida Da Silva Pedro E PE Rabinowitz Peter P da Cunha Rivaldo V RV Trinta Karen S KS do Carmo Said Rodrigo F RF Kato Rodrigo R Stabeli Rodrigo R de Jesus Ronaldo R Hans Santos Roselene R Kashima Simone S Slavov Svetoslav N SN Andrade Tamires T Rocha Themis T Carneiro Thiago T Nardy Vanessa V da Silva Vinicius V Carvalho Walterlene G WG Van Voorhis Wesley C WC Araujo Wildo N WN de Filippis Ana M B AMB Giovanetti Marta M

Nature communications 20230721 1

The emergence and reemergence of mosquito-borne diseases in Brazil such as yellow fever, zika, chikungunya, and dengue have had serious impacts on public health. Concerns have been raised due to the rapid dissemination of the chikungunya virus across the country since its first detection in 2014 in Northeast Brazil. In this work, we carried out on-site training activities in genomic surveillance in partnership with the National Network of Public Health Laboratories that have led to the generatio ...[more]

PMID: 37479700

Similar Datasets

Project description:Dengue viruses are the most important arboviral pathogens in the world, which have adapted to human transmission and replication over several hundred years and were initially recognized to cause outbreaks of clinical disease in tropical and subtropical countries by Aedes aegypti mosquitoes. Subsequent global expansion of dengue infection outbreaks has occurred, with millions of cases yearly, probably from a combination of factors including proliferation of international travel and trade, possibly global climate changes, adaptation of the vectors to new environment, and emergence of a new mosquito vector, Aedes albopictus. Chikungunya virus, also transmitted by Aedes mosquitoes, causes a very similar clinical disease but with more prominent arthralgia or arthritis and was originally described in Africa in the 1960s. After a quiescent period of several decades, it reemerged in Africa in 2004 and rapidly spread across the Indian Ocean to involve Asian countries and parts of Europe. However, the past 2 years have seen the emergence of chikungunya virus in the western hemisphere with major outbreaks in the Caribbean and the Americas. Similar to dengue virus, chikungunya virus has adapted to Ae. albopictus mosquitoes which can transmit the disease. Although dengue infection is a more deadly disease especially in young children, chikungunya infection can cause prolonged severe disability and occasionally rare fatalities from encephalitis. No specific treatment is available for either diseases, but development of an effective vaccine for dengue infection is in progress. Until 2007, Zika virus [also transmitted by Aedes species] was associated with only sporadic mild infections in Africa and Asia. In 2007, Zika virus for the first time caused an outbreak beyond Africa and Asia to the Yap Island in the Federated States of Micronesia. Since then Zika virus has spread to French Polynesia, New Caledonia, Cook Islands, and Easter Island in the southeastern Pacific Ocean [Chile] in 2014 and by 2015 to Brazil. By January 2016, it became evident that Zika virus had caused an explosive outbreak in the Americas and the Caribbean with over 30 countries affected. On February 1, 2016, the World Health Organization declared Zika outbreak a global public health emergency. Zika virus infection is most commonly asymptomatic, and 20% of patients may develop a mild viral disease, but of major concern is the reported association of microcephaly in infected pregnant women in Brazil. This chapter explores the history, epidemiology, pathogenesis, clinical features, treatment, and prevention of these rapidly emerging zoonoses.

Dataset Information

Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil.

Publications

Increased interregional virus exchange and nucleotide diversity outline the expansion of chikungunya virus in Brazil.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets