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An exploratory study on the association between serotonin and sleep breathing disorders.


ABSTRACT: This exploratory observational study aimed to evaluate whether the blood levels of serotonin and enzymes involved in serotonin synthesis are associated with sleep breathing parameters. A total of 105 patients were included in this study, who were subjected to single-night polysomnography with simultaneous audio-video recordings. Peripheral blood samples were collected to estimate the serum levels of serotonin, tryptophan hydroxylase 1 (TPH1), and aromatic l-amino acid decarboxylase (AADC). Results showed a negative correlation between blood serotonin levels, and oxygen desaturation index (ODI) (p = 0.027), central apnea (p = 0.044) and obstructive apnea (OA) (p = 0.032) scores. Blood TPH1 levels were negatively correlated with average (p = 0.003) and minimal saturation (p = 0.035) and positively correlated with apnea-hypopnea index (p = 0.010), OA (p = 0.049), and hypopnea index (p = 0.007) scores. A tendency to sleep-disordered breathing seemed to co-occur with lower blood serotonin and higher TPH1 levels.Clinical Trial Registration : www.ClinicalTrials.gov , identifier NCT04214561.

SUBMITTER: Wieckiewicz M 

PROVIDER: S-EPMC10362063 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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An exploratory study on the association between serotonin and sleep breathing disorders.

Wieckiewicz Mieszko M   Martynowicz Helena H   Lavigne Gilles G   Lobbezoo Frank F   Kato Takafumi T   Winocur Efraim E   Wezgowiec Joanna J   Danel Dariusz D   Wojakowska Anna A   Mazur Grzegorz G   Smardz Joanna J  

Scientific reports 20230721 1


This exploratory observational study aimed to evaluate whether the blood levels of serotonin and enzymes involved in serotonin synthesis are associated with sleep breathing parameters. A total of 105 patients were included in this study, who were subjected to single-night polysomnography with simultaneous audio-video recordings. Peripheral blood samples were collected to estimate the serum levels of serotonin, tryptophan hydroxylase 1 (TPH1), and aromatic l-amino acid decarboxylase (AADC). Resul  ...[more]

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