Ru(phen)₃ Cl₂ -Catalyzed Chlorotrifluoromethylation of Unactivated Alkenes.

ABSTRACT: A novel Ru(phen)₃ Cl₂ -catalyzed free-radical chlorotrifluoromethylation reaction of unactivated olefins was investigated. Substituted 8-aminoquinoline-derived inert enamides were reacted with the Togni regent to afford a broad range of Cl-containing trifluoromethyl derivatives in good yields. The reaction proceeded at 90 °C and experimental result shows that the chlorine source of the products originated from LiCl.

SUBMITTER: Su W 

PROVIDER: S-EPMC10362121 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature