Cortical microvascular blood flow velocity mapping by combining dynamic light scattering optical coherence tomography and two-photon microscopy.

ABSTRACT:

Significance

The accurate large-scale mapping of cerebral microvascular blood flow velocity is crucial for a better understanding of cerebral blood flow (CBF) regulation. Although optical imaging techniques enable both high-resolution microvascular angiography and fast absolute CBF velocity measurements in the mouse cortex, they usually require different imaging techniques with independent system configurations to maximize their performances. Consequently, it is still a challenge to accurately combine functional and morphological measurements to co-register CBF speed distribution from hundreds of microvessels with high-resolution microvascular angiograms.

Aim

We propose a data acquisition and processing framework to co-register a large set of microvascular blood flow velocit

SUBMITTER: Pian Q 

PROVIDER: S-EPMC10362155 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature