A point-of-care pharmacokinetic/pharmacodynamic trial in critically ill children: Study design and feasibility.

ABSTRACT:

Background

High-quality, efficient, pharmacokinetic (PK), pharmacodynamic (PD), and safety studies in children are needed. Point-of-care trials in adults have facilitated clinical trial participation for patients and providers, minimized the disruption of clinical workflow, and capitalized on routine data collection. The feasibility and value of point-of-care trials to study PK/PD in children are unknown, but appear promising. The Opportunistic PK/PD Trial in Critically Ill Children with Heart Disease (OPTIC) is a programmatic point-of-care approach to PK/PD trials in critically ill children that seeks to overcome barriers of traditional pediatric PK/PD studies to generate safety, efficacy, PK, and PD data across multiple medications, ages, and disease processes.

Methods

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SUBMITTER: Thompson EJ 

PROVIDER: S-EPMC10362170 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature