Moderate-intensity endurance training improves late phase β-cell function in adults with type 2 diabetes.

ABSTRACT: Physical activity is important for type 2 diabetes treatment, yet the underlying mechanisms for these beneficial effects of exercise are not fully understood. Here, we investigated the effects of exercise training on biphasic β-cell insulin secretory function, a key factor regulating blood glucose. Adults with type 2 diabetes (7F/3M, age 49 ± 5 years, BMI 30 ± 3 kg/m²) completed a 10-week moderate-intensity exercise program and multiple components of glucose homeostasis were measured. Training improved glycemic control, insulin sensitivity, and processing of proinsulin-to-insulin. Training increased late phase β-cell function by 38% (p = 0.01), which was correlated with changes in VO_2peak suggesting training response-dependent effects. Ras-Responsive Element Binding P

SUBMITTER: Zhang H 

PROVIDER: S-EPMC10362261 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature