Ontology highlight
ABSTRACT:
SUBMITTER: Tsusaka T
PROVIDER: S-EPMC10362303 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Tsusaka Takeshi T Oses-Prieto Juan A JA Lee Christina C DeFelice Brian C BC Burlingame Alma L AL Goldberg Emily L EL
iScience 20230629 7
Ketone bodies are short-chain fatty acids produced in the liver during periods of limited glucose availability that provide an alternative energy source for the brain, heart, and skeletal muscle. Beyond this metabolic role, β-hydroxybutyrate (BHB), is gaining recognition as a signaling molecule. Lysine β-hydroxybutyrylation (Kbhb) is a newly discovered post-translational modification in which BHB is covalently attached to lysine ε-amino groups. This protein adduct is metabolically sensitive, dep ...[more]