Short-term blood pressure variability is inversely related to regional amplitude of low frequency fluctuations in older and younger adults.

ABSTRACT: Blood pressure variability (BPV), independent of mean blood pressure levels, is associated with cerebrovascular disease burden on MRI and postmortem evaluation. However, less is known about relationships with markers of cerebrovascular dysfunction, such as diminished spontaneous brain activity as measured by the amplitude of low frequency fluctuations (ALFF), especially in brain regions with vascular and neuronal vulnerability in aging. We investigated the relationship between short-term BPV and concurrent regional ALFF from resting state fMRI in a sample of community-dwelling older adults (n = 44) and healthy younger adults (n = 49). In older adults, elevated systolic BPV was associated with lower ALFF in widespread medial temporal regions and the anterior cingulate cortex.

SUBMITTER: Sible IJ 

PROVIDER: S-EPMC10362312 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature