Biomaterial-enabled therapeutic modulation of cGAS-STING signaling for enhancing antitumor immunity.

ABSTRACT: cGAS-STING signaling is a central component in the therapeutic action of most existing cancer therapies. The accumulated knowledge of tumor immunoregulatory network in recent years has spurred the development of cGAS-STING agonists for tumor treatment as an effective immunotherapeutic strategy. However, the clinical translation of these agonists is thus far unsatisfactory because of the low immunostimulatory efficacy and unrestricted side effects under clinically relevant conditions. Interestingly, the rational integration of biomaterial technology offers a promising approach to overcome these limitations for more effective and safer cGAS-STING-mediated tumor therapy. Herein, we first outline the cGAS-STING signaling axis and generally discuss its association with tumors. We then symmetric

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10362396 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature