Exercise training attenuates angiotensin II-induced cardiac fibrosis by reducing POU2F1 expression.

ABSTRACT:

Background

Exercise training protects against heart failure. However, the mechanism underlying the protective effect of exercise training on angiotensin II (Ang II)-induced cardiac fibrosis remains unclear.

Methods

An exercise model involving C57BL/6N mice and 6 weeks of treadmill training was used. Ang II (1.44 mg/kg/day) was administered to induce cardiac fibrosis. RNA sequencing and bioinformatic analysis were used to identify the key factors mediating the effects of exercise training on cardiac fibrosis. Primary adult mouse cardiac fibroblasts (CFs) were used in vitro. Adeno-associated virus serotype 9 was used to overexpress POU domain, class 2, transcription factor 1 (POU2F1) in vivo.

Results

Exercise training attenuated Ang II-induced cardiac fibrosis and rever

SUBMITTER: Feng N 

PROVIDER: S-EPMC10362488 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature