Genome architecture and selective signals compensatorily shape plastic response to a new environment.

ABSTRACT: Transcriptional plasticity interacts with natural selection in complex ways and is crucial for the survival of species under rapid climate change. How 3D genome architecture affects transcriptional plasticity and its interaction with genetic adaptation are unclear. We transplanted estuarine oysters to a new environment and found that genes located in active chromatin regions exhibited greater transcriptional plasticity, and changes in these regions were negatively correlated with selective signals. This indicates a trade-off between 3D active regions and selective signals in shaping plastic responses to a new environment. Specifically, a mutation, lincRNA, and changes in the accessibility of a distal enhancer potentially affect its interaction with the ManⅡa gene, which regulates th

SUBMITTER: Li A 

PROVIDER: S-EPMC10362523 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature