C-Reactive protein and cognition: Mediation analyses with brain morphology in the UK Biobank.

ABSTRACT: Cognitive impairments and abnormal immune activity are both associated with various clinical disorders. The association between C-Reactive protein (CRP), a marker associated with inflammation, and cognitive performance remains unclear. Further, mechanisms potentially linking CRP to cognition are not yet established. Brain structure may well mediate this relationship: immune processes play crucial roles in shaping and maintaining brain structure, with brain structure and function driving cognition. The United Kingdom Biobank (UKBB) is a large cohort study with extensive assessments, including high-sensitivity serum CRP levels, brain imaging, and various cognitive tasks. With data from 39,200 UKBB participants, we aimed first to determine the relationship between CRP and cognitive performanc

SUBMITTER: Mendelson D 

PROVIDER: S-EPMC10362544 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature