The Vasopressin Loading for Refractory septic shock (VALOR) study: a prospective observational study.

ABSTRACT:

Background

Vasopressin is a second-line vasoactive agent for refractory septic shock. Vasopressin loading is not generally performed because of the lack of evidence for its effects and safety. However, based on our previous findings, we hypothesized it can predict the responsibility to vasopressin infusion with safety, and prospectively examined it in the present study.

Methods

Vasopressin loading was performed via the intravenous administration of a bolus of 1 U, followed by its continuous infusion at 1U/h in patients with septic shock treated with ≥ 0.2 μg/kg/min noradrenaline. An arterial pressure wave analysis was conducted, and endocrinological tests were performed immediately prior to vasopressin loading. We classified patients into responders/non-responders based on m

SUBMITTER: Nakamura K 

PROVIDER: S-EPMC10362561 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature