The potential roles of cigarette smoke-induced extracellular vesicles in oral leukoplakia.

ABSTRACT:

Background

The onset of oral leukoplakia (OLK), the most common oral lesion with a high risk of malignant transformation, is closely associated with the exposure of cigarette smoke. Cigarette smoke is a complicated mixture of more than 4500 different chemicals including various oxidants and free radical, which contributes to the onset of immune and inflammatory response or even carcinogenesis. Recent studies have proved that the exposure of cigarette smoke leads to the onset and aggravation of many diseases via significantly changed the production and components of extracellular vesicles. The extracellular vesicles are membrane-enclosed nanosized particles secreted by diverse cells and involved in cell-cell communication because of their ability to deliver a number of bioactive mol

SUBMITTER: Peng Q 

PROVIDER: S-EPMC10362576 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature