Patient-derived organoids for precision oncology: a platform to facilitate clinical decision making.

ABSTRACT:

Background

Despite recent advances in research, there are still critical lacunae in our basic understanding of the cause, pathogenesis, and natural history of many cancers, especially heterogeneity in patient response to drugs and mediators in the transition from malignant to invasive phenotypes. The explication of the pathogenesis of cancer has been constrained by limited access to patient samples, tumor heterogeneity and lack of reliable biological models. Amelioration in cancer treatment depends on further understanding of the etiologic, genetic, biological, and clinical heterogeneity of tumor microenvironment. Patient-derived organoids recapitulate the basic features of primary tumors, including histological complexity and genetic heterogeneity, which is instrumental in predict

SUBMITTER: Chitrangi S 

PROVIDER: S-EPMC10362580 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature