Screening of hub inflammatory bowel disease biomarkers and identification of immune-related functions based on basement membrane genes.

ABSTRACT:

Background

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic, inflammatory, and autoimmune disease, but its specific etiology and pathogenesis are still unclear. This study aimed to better discover the causative basement membrane (BM) genes of their subtypes and their associations.

Methods

The differential expression of BM genes between CD and UC was analyzed and validated by downloading relevant datasets from the GEO database. We divided the samples into 3 groups for comparative analysis. Construction of PPI networks, enrichment of differential gene functions, screening of Lasso regression models, validation of ROC curves, nomogram for disease prediction and other analytical methods were used. The immune cell infiltra

SUBMITTER: Lin P 

PROVIDER: S-EPMC10362583 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature