Blood monocyte and dendritic cell profiles among people living with HIV with Mycobacterium tuberculosis co-infection.

ABSTRACT:

Background

Understanding the complex interactions of the immune response mediated by Mycobacterium tuberculosis and HIV co-infection is fundamental to disease biomarker discovery, vaccine, and drug development. Using flow cytometry, we characterized the frequencies and phenotypic differences in monocytes and dendritic cell populations using peripheral blood mononuclear cells from individuals with recurrent, active pulmonary tuberculosis with and without coexisting HIV infection (CAPRISA 011, Clinicaltrials.gov, NCT02114684, 29/01/2014) and compared them to samples from HIV positive individuals and healthy controls. Additionally, we assessed the associations between the frequency of monocyte and dendritic cell subsets and time to culture conversion and cavitary disease in patients w

SUBMITTER: Rambaran S 

PROVIDER: S-EPMC10362598 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature