Downregulation of MAL2 inhibits breast cancer progression through regulating β-catenin/c-Myc axis.

ABSTRACT:

Purpose

Myelin and lymphocyte protein 2 (MAL2) is mainly involved in endocytosis under physiological conditions and mediates the transport of materials across the membranes of cell and organelle. It has been reported that MAL2 is significantly upregulated in diverse cancers. This study aimed to investigate the role of MAL2 in breast cancer (BC).

Methods

Bioinformatics analysis and Immunohistochemical assay were applied to detect the correlation between MAL2 expression in breast cancer tissues and the prognosis of breast cancer patients. Functional experiments were carried out to investigate the role of MAL2 in vitro and in vivo. The molecular mechanisms involved in MAL2-induced β-catenin and c-Myc expression and β-catenin/c-Myc-mediated enhancement of BC progression were con

SUBMITTER: An L 

PROVIDER: S-EPMC10362617 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature