Association between intrapleural urokinase monotherapy and treatment failure in patients with pleural infection: a retrospective cohort study.

ABSTRACT:

Background

Pleural infection, an infection of the pleural space, is frequently treated with antibiotics and thoracic tube drainage. In case of insufficient drainage, an intrapleural fibrinolytic agent is considered before surgical intervention. However, the effectiveness of fibrinolytic monotherapy is still controversial. Therefore, we aimed to examine the association between urokinase monotherapy and treatment failure in patients with pleural infection.

Methods

In this retrospective observational study, patients with pleural infection underwent chest tube insertion were divided into two groups including patients treated with or without intrapleural instillation of urokinase. The propensity score overlap weighting was used to balance the baseline characteristics between the

SUBMITTER: Taniguchi J 

PROVIDER: S-EPMC10362621 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature