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XenoGI 3: using the DTLOR model to reconstruct the evolution of gene families in clades of microbes.


ABSTRACT: To understand genome evolution in a group of microbes, we need to know the timing of events such as duplications, deletions and horizontal transfers. A common approach is to perform a gene-tree / species-tree reconciliation. While a number of software packages perform this type of analysis, none are geared toward a complete reconstruction for all families in an entire clade. Here we describe an update to the xenoGI software package which allows users to perform such an analysis using the newly developed DTLOR (duplication-transfer-loss-origin-rearrangement) reconciliation model starting from genome sequences as input.

SUBMITTER: Liu N 

PROVIDER: S-EPMC10362622 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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xenoGI 3: using the DTLOR model to reconstruct the evolution of gene families in clades of microbes.

Liu Nuo N   Gonzalez Tonatiuh A TA   Fischer Jacob J   Hong Chan C   Johnson Michelle M   Mawhorter Ross R   Mugnatto Fabrizia F   Soh Rachael R   Somji Shifa S   Wirth Joseph S JS   Libeskind-Hadas Ran R   Bush Eliot C EC  

BMC bioinformatics 20230721 1


To understand genome evolution in a group of microbes, we need to know the timing of events such as duplications, deletions and horizontal transfers. A common approach is to perform a gene-tree / species-tree reconciliation. While a number of software packages perform this type of analysis, none are geared toward a complete reconstruction for all families in an entire clade. Here we describe an update to the xenoGI software package which allows users to perform such an analysis using the newly d  ...[more]

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