Causal effects of serum lipid biomarkers on early age-related macular degeneration using Mendelian randomization.

ABSTRACT:

Background

Age-related macular degeneration (AMD) is one of the major causes of vision loss. Early AMD needs to be taken seriously, but the causal effects of lipid biomarkers on early AMD remain unclear.

Methods

In this study, two-sample Mendelian randomization (MR) analysis was performed to systematically assess the causal relationships between seven serum lipid biomarkers (apolipoprotein A (ApoA), apolipoprotein B (ApoB), total cholesterol (CHOL), high-density lipoprotein cholesterol (HDL-C), direct low-density lipoprotein cholesterol (LDL-C), lipoprotein A [Lp(a)], and triglycerides (TG)) and risk of early AMD. In total, 14,034 cases and 91,214 controls of European ancestry were included in the analysis (number of SNPs = 11,304,110).

Results

MR estimates revealed t

SUBMITTER: Li FF 

PROVIDER: S-EPMC10362672 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature