Early administration of multiple vasopressors is associated with better survival in patients with sepsis: a propensity score-weighted study.

ABSTRACT:

Background

The association between the timing of administration of multiple vasopressors and patient outcomes has not been investigated.

Methods

This study used data from the MIMIC-IV database. Patients with sepsis who were administered two or more vasopressors were included. The principal exposure was the last norepinephrine dose when adding a second vasopressor. The cohort was divided into early (last norepinephrine dose < 0.25 μg/kg/min) and normal (last norepinephrine dose ≥ 0.25 μg/kg/min) groups. The primary outcome was 28-day mortality. Multivariable Cox analyses, propensity score matching, stabilized inverse probability of treatment weighting (sIPTW), and restricted cubic spline (RCS) curves were used.

Results

Overall, 1,437 patients who received multiple vaso

SUBMITTER: Tong X 

PROVIDER: S-EPMC10362716 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature