Diagnostic and therapeutic practices in adult chronic nonbacterial osteomyelitis (CNO).

ABSTRACT:

Background

Chronic nonbacterial osteomyelitis (CNO) is a rare, and impactful auto-inflammatory bone disease occurring in children and adults. Clinical care for CNO is challenging, as the condition lacks validated classification criteria and evidence-based therapies. This study aimed to map the current diagnostic and therapeutic practices for CNO in adults, as a first step towards a standardized disease definition and future consensus treatment plans.

Methods

A primary survey was spread among global rheumatological/bone networks and 57 experts as identified from literature (May 2022), covering terminology, diagnostic tools (clinical, radiological, biochemical) and treatment steps. A secondary survey (sent to primary survey responders in August 2022) further queried key diagno

SUBMITTER: Leerling AT 

PROVIDER: S-EPMC10362746 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature